Oxygen-Transporting Parylene-HT Mesh for Cell Transplantation to Reduce Hypoxia
Abstract
Cell transplantation is a way of treatment in which lost cellular functions can be recovered by transplanted cells. However, hypoxic conditions on the transplanted site hinder the survival of the cells. This paper presents an oxygenation device for cell transplantations to improve the engraftment and transplanted cell survival. The flexible and thin polymeric hollow mesh working as gas capillaries can effectively transport oxygen between microvessels and transplanted cells, maintaining adequate oxygen tension for cell survival and functionality. Devices are designed, fabricated, and characterized in this study. Both in silico and in vivo models demonstrate a 4-5 fold increase in cell viability compared to the control group without oxygen-transporting mesh. The results showed that a broad spectrum of cell transplantations could benefit from such MEMS oxygen-transporting device.
Additional Information
© 2021 IEEE. The authors would like to thank Drs. Colin Cook and Nicholas Scianmarello for the advice and discussion of the computational model construction. We also thank Dr. Sung Hee Kil for the critical reading and editing of the manuscript.Additional details
- Eprint ID
- 108773
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- CaltechAUTHORS:20210420-100830806
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2021-04-21Created from EPrint's datestamp field
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2021-04-21Created from EPrint's last_modified field