Light-Adjustable Lens: Development of in Vitro Nomograms
Abstract
Purpose: To determine whether digital spatial intensity patterns can be developed to effect precise in vitro correction of myopic, hyperopic, and astigmatic refractive errors in a silicone light-adjustable lens (LAL). Also, to determine whether a new spatial intensity pattern for "lock-in" is effective in vitro. Methods: A digital interferometer/irradiation system was developed to irradiate LALs and measure the power change following irradiation. Light-adjustable lenses were mounted into a wet cell maintained at 35.0 ± 0.5°C (simulated ocular temperature) and allowed to equilibrate for a minimum of 2 hours. Ultraviolet light was then applied with spatial light intensity patterns to correct hyperopia, myopia, and astigmatism. Light-adjustable lenses were also treated to effect lock-in with a separate spatial light intensity pattern. Treated lenses were characterized for power change and optical quality. In the case of lock-in, exhaustive chemical extraction was also performed to determine the percentage of remaining macromer. Results: Appropriate digital irradiation spatial intensity patterns were created to develop nomograms for in vitro correction of myopia, hyperopia, and astigmatism in approximate 0.25 D steps. Power changes were reproducible and did not alter optical quality of the LALs. Further, lock-in dosing of the LALs did not alter optical quality or significantly change LAL power. Conclusions: In vitro nomograms have been developed for a silicone LAL that permit precise correction of myopia, hyperopia, and astigmatism. Furthermore, a spatial light intensity pattern has been devised that effects lock-in without significantly altering LAL power or optical quality.
Additional Information
© 2004 American Ophthalmological Society. This work is supported by grant 2R44EY012181-02 from the National Eye Institute. The authors state that they have a proprietary interest in the product described in this article.Attached Files
Published - tao102pg067.pdf
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Additional details
- PMCID
- PMC1280088
- Eprint ID
- 108367
- Resolver ID
- CaltechAUTHORS:20210309-115036488
- 2R44EY012181-02
- NIH
- Created
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2021-03-10Created from EPrint's datestamp field
- Updated
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2021-03-10Created from EPrint's last_modified field