Published January 2006
| public
Journal Article
Synthesis of Chlorambucil-Tempol Adduct and its Delivery using Fluoroalkyl Double-Ended Poly (Ethylene Glycol) Micelles
Abstract
In our pursuit to find potent anticancer drugs, we have covalently bonded free radical tempol to chlorambucil giving a chlorambucil-tempol (CT) adduct in which both of the anticancer active sites in tempol and chlorambucil were left intact. Analysis using NMR, Maldi-TOF, and EPR verified the designed chemical structure. Because the CT adduct is more hydrophobic than chlorambucil, its delivery also was investigated using fluoroalkyl double-ended poly (ethylene glycol) (R_f-PEG) micelles. Results from EPR spectra and¹⁹ F and¹ H NMR spin lattice relaxation times show that the R_f-PEG micelles are able to encapsulate CT into the R_f cores of the micelles.
Additional Information
© 2006 Informa Healthcare. Received 20 Aug 2005, Accepted 18 Nov 2005, Published online: 10 Oct 2008. This project is supported by NSF grant award #0351848. Thanks to the Department of Defense for funding the EPR spectrometer under grant d20030904hsi. Thanks to Dr. Y. Mao for his assistance in the EPR experiments.Additional details
- Eprint ID
- 108363
- Resolver ID
- CaltechAUTHORS:20210309-105356346
- DMR-0351848
- NSF
- d20030904hsi
- Department of Defense
- Created
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2021-03-10Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field