A functional logic for neurotransmitter co-release in the cholinergic forebrain pathway

Creators: Nair, Aditya; Graf, Martin; Teo, Yue Yang; Augustine, George J.

Abstract

The forebrain cholinergic system has recently been shown to co-release both acetylcholine and GABA. We have discovered that such co-release by cholinergic inputs to the claustrum differentially affects neurons that project to cortical versus subcortical targets. The resulting changes in neuronal gain toggles network efficiency and discriminability of output between two different projection subcircuits. Our results provide a potential logic for neurotransmitter co-release in cholinergic systems.

Additional Information

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. This version posted February 25, 2021. Code used for analysis of IO curves and the recurrent claustrum network is available at https://github.com/adityanairneuro/cholinergic. We thank K.L.L Wong, Z. Chia, G. X. Ham, L. Mark, and G. Silberberg for insightful discussions and comments on our paper and K. Chung, P. Teo, S. Kay, R. Tan, and Y. C. Teo for technical assistance. Supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2017-T3-1-002). A.N is supported by a National Science Scholarship awarded by the Agency of Science, Technology and Research, Singapore. The authors declare no competing financial interests.

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