Published January 2021
| Published
Journal Article
Open
Dynamic patterning by morphogens illuminated by cis-regulatory studies
- Creators
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Irizarry, Jihyun
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Stathopoulos, Angelike
Chicago
Abstract
Morphogen concentration changes in space as well as over time during development. However, how these dynamics are interpreted by cells to specify fate is not well understood. Here, we focus on two morphogens: the maternal transcription factors Bicoid and Dorsal, which directly regulate target genes to pattern Drosophila embryos. The actions of these factors at enhancers has been thoroughly dissected and provides a rich platform for understanding direct input by morphogens and their changing roles over time. Importantly, Bicoid and Dorsal do not work alone; we also discuss additional inputs that work with morphogens to control spatiotemporal gene expression in embryos.
Additional Information
© 2021. Published by The Company of Biologists Ltd. We are grateful to Leslie Dunpiace, Susie Newcomb and Ellen Rothenberg for comments on the manuscript. The authors' research is funded by the National Institutes of Health (R21HD095639 and R35GM118146 to A.S.). Deposited in PMC for release after 12 months. The authors declare no competing or financial interests.Attached Files
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Additional details
- PMCID
- PMC7847269
- Eprint ID
- 107623
- Resolver ID
- CaltechAUTHORS:20210121-101410191
- NIH
- R21HD095639
- NIH
- R35GM118146
- Created
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2021-01-21Created from EPrint's datestamp field
- Updated
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2022-02-08Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering