Published July 22, 2001
| public
Journal Article
Interaction between directional epistasis and average mutational effects
- Creators
- Wilke, Claus O.
- Christoph, Adami
Abstract
We investigate the relationship between the average fitness decay due to single mutations and the strength of epistatic interactions in genetic sequences. We observe that epistatic interactions between mutations are correlated to the average fitness decay, both in RNA secondary structure prediction as well as in digital organisms replicating in silico. This correlation implies that, during adaptation, epistasis and average mutational effect cannot be optimized independently. In experiments with RNA sequences evolving on a neutral network, the selective pressure to decrease the mutational load then leads to a reduction in the amount of sequences with strong antagonistic interactions between deleterious mutations in the population.
Additional Information
© 2002 The Royal Society. Published online: 22/07/2001; Published in print: 22/07/2001. We thank Martijn Huynen for providing access to the sequences used in Van Nimwegen et al. (1999) and Walter Fontana for providing us with his flow reactor code. We are grateful to Richard Lenski and two anonymous referees for many useful comments and suggestions regarding the manuscript. The genomes of digital organisms used in this study are available at http:dlab.caltech.edu/pubs/nature99/nature.shtml. This work was supported by the National Science Foundation under contract no. DEB-9981397.Additional details
- PMCID
- PMC1088765
- Eprint ID
- 107107
- Resolver ID
- CaltechAUTHORS:20201215-153415616
- DEB-9981397
- NSF
- Created
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2020-12-16Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field