Genetic analysis of the Shaker gene complex of Drosophila melanogaster
Abstract
The Shaker complex (ShC) spans over 350 kb in the 16F region of the X chromosome. It can be dissected by means of aneuploids into three main sections: the maternal effect (ME), the viable (V) and the haplolethal (HL) regions. The mutational analysis of ShC shows a high density of antimorphic mutations among 12 lethal complementation groups in addition to 14 viable alleles. The complex is the structural locus of a family of potassium channels as well as a number of functions relevant to the biology of the nervous system. The constituents of ShC seem to be linked by functional relationships in view of the similarity of the phenotypes, antimorphic nature of their mutations and the behavior in transheterozygotes. We discuss the relationship between the genetic organization of ShC and the functional coupling of potassium currents with the other functions encoded in the complex.
Additional Information
© 1990 Genetics Society of America. Published online June 1, 1990. This report is the account of ten years of work on this subject. It began at the California Institute of Technology, continued under very difficult conditions at the Centro de Biologia Molecular and finished at the Instituto Cajal. We wish to thank those colleagues who helped and encouraged us during these years in various ways, most notably: S. BENZER and J. MODOLELL. Also we are indebted to J. MERRIAM and G. LEFEVRE who provided essential chromosomal rearrangements. Our colleagues in the laboratories of Madrid and Bochum contributed with their criticisms. Funds were obtained from the Comisión Asesora de Investigación Cientifica y Técnica, the Volkswagen Stiftung and the programme Acciones Integradas between Spain and Germany.Attached Files
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Additional details
- PMCID
- PMC1204027
- Eprint ID
- 107033
- Resolver ID
- CaltechAUTHORS:20201210-164442390
- Comisión Asesora de Investigación Cientifica y Técnica (CAICYT)
- Volkswagen Stiftung
- Acciones Integradas
- Created
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2020-12-11Created from EPrint's datestamp field
- Updated
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2020-12-11Created from EPrint's last_modified field