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Published December 10, 2020 | Accepted Version
Journal Article Open

Principles of Self-Organization of the Mammalian Embryo

Abstract

Early embryogenesis is a conserved and self-organized process. In the mammalian embryo, the potential for self-organization is manifested in its extraordinary developmental plasticity, allowing a correctly patterned embryo to arise despite experimental perturbation. The underlying mechanisms enabling such regulative development have long been a topic of study. In this Review, we summarize our current understanding of the self-organizing principles behind the regulative nature of the early mammalian embryo. We argue that geometrical constraints, feedback between mechanical and biochemical factors, and cellular heterogeneity are all required to ensure the developmental plasticity of mammalian embryo development.

Additional Information

© 2020 Published by Elsevier. Available online 10 December 2020. We thank David Glover, Marta Shahbazi, Berna Sozen, Adiyant Lamba, and Min Bao for the constructive comments on the review. The work in the M.Z.-G. lab is supported by Wellcome Trust (098287/Z/12/Z), ERC (669198), Luverhulme Trust (RPG-2018-085), National Institutes of Health (R01 HD100456-01A1, 1DP1HD104575-01), Curci and Weston Havens Foundations, and Open Philanthropy grants.

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