Principles of Self-Organization of the Mammalian Embryo
- Creators
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Zhu, Meng
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Zernicka-Goetz, Magdalena
Abstract
Early embryogenesis is a conserved and self-organized process. In the mammalian embryo, the potential for self-organization is manifested in its extraordinary developmental plasticity, allowing a correctly patterned embryo to arise despite experimental perturbation. The underlying mechanisms enabling such regulative development have long been a topic of study. In this Review, we summarize our current understanding of the self-organizing principles behind the regulative nature of the early mammalian embryo. We argue that geometrical constraints, feedback between mechanical and biochemical factors, and cellular heterogeneity are all required to ensure the developmental plasticity of mammalian embryo development.
Additional Information
© 2020 Published by Elsevier. Available online 10 December 2020. We thank David Glover, Marta Shahbazi, Berna Sozen, Adiyant Lamba, and Min Bao for the constructive comments on the review. The work in the M.Z.-G. lab is supported by Wellcome Trust (098287/Z/12/Z), ERC (669198), Luverhulme Trust (RPG-2018-085), National Institutes of Health (R01 HD100456-01A1, 1DP1HD104575-01), Curci and Weston Havens Foundations, and Open Philanthropy grants.Attached Files
Accepted Version - nihms-1715034.pdf
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Additional details
- PMCID
- PMC8212876
- Eprint ID
- 107022
- DOI
- 10.1016/j.cell.2020.11.003
- Resolver ID
- CaltechAUTHORS:20201210-160239379
- Wellcome Trust
- 098287/Z/12/Z
- European Research Council (ERC)
- 669198
- Luverhulme Trust
- RPG-2018-085
- NIH
- R01 HD100456-01A1
- NIH
- 1DP1HD104575-01
- Shurl and Kay Curci Foundation
- Weston Havens Foundation
- Open Philanthropy
- Created
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2020-12-11Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering (BBE)