SARS-CoV-2 B cell receptor signatures in at-risk populations
- Creators
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Flyak, Andrew I.
Abstract
Many individuals possess B cells capable of recognizing epitopes on the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this issue of the JCI, Paschold and Simnica et al. interrogated the frequency of SARS-CoV-2–specific B cell receptor rearrangements in healthy subjects based on age and cancer status. The authors found that while SARS-CoV-2–specific antibody signatures can be identified in the repertoires of young, healthy individuals, such sequences are less frequent in elderly subjects or patients with cancer. Overall, this study sheds light on B cell repertoire restrictions that might lead to an unfavorable clinical course of coronavirus disease 2019 infection in at-risk populations.
Additional Information
© 2021 American Society for Clinical Investigation. Published November 20, 2020. AIF is supported by a research funding from the National Institutes of Health grant K99 AI153465 (content is solely the responsibility of the author and does not necessarily represent the official views of the NIH). AIF acknowledges Pamela J. Bjorkman for critical reading of the manuscript. The author has declared that no conflict of interest exists.Attached Files
Published - jci-131-144685.pdf
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Additional details
- PMCID
- PMC7773361
- Eprint ID
- 106872
- Resolver ID
- CaltechAUTHORS:20201202-081646342
- K99 AI153465
- NIH
- Created
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2020-12-02Created from EPrint's datestamp field
- Updated
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2023-07-17Created from EPrint's last_modified field
- Caltech groups
- COVID-19