Molecular Models of Amino Acids, Peptides, and Proteins

Creators: Corey, Robert B.; Pauling, Linus

Abstract

A set of accurate scale models has been developed for use in studies of the structures of amino acids, peptides, and proteins. Models representing atoms or groups of atoms built from hard wood to the scale 1 in.=1A are connected by a clamping device which maintains desired molecular configurations. These accurate models have been used as substitutes for calculation in investigations of the probable configuration of the polypeptide chain in proteins. Analogous models constructed of rubber‐like plastic to the scale 1 in.=2A and connected by snap fasteners are designed for qualitative studies of protein structure.

Additional Information

© 1953 American Institute of Physics. (Received August 25, 1952) Aided by a grant from the National Foundation for Infantile Paralysis. The development of the molecular models described in this paper has been a collaborative effort in which many members of the staff of the California Institute of Technology have participated. We are especially grateful to Roger Hayward and William W. Schuelke for their ingenious solutions of many of the problems of design and construction, to Delmer D. Dill for his excellent workmanship, and to many members of the Institute faculty for their criticisms and suggestions. For five years this work was aided by a grant from the National Foundation for Infantile Paralysis; more recently it has been aided by a grant from the National Institutes of Health, U. S. Public Health Service.

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