Software for electrophysiological experiments with a personal computer
Abstract
These programs were written for the IBM personal computer equipped with a Tecmar Labmaster analog interface board. The software operates under the MS-DOS operating system; it is written in compiled BASIC and employs short machine-language subroutines for crucial functions. Details are presented on the analog interface routines which make special use of the 9513 counter/timer chip on the Labmaster. Time resolution is about 32 μs per sample on the PC and 15 μs on the PC/AT. One series of programs performs traditional voltage- and current-clamp experiments on macroscopic currents in whole cells. A second series interfaces with a hardware window discriminator to capture single-channel events in a recirculating buffer, a stimulus can be triggered to fire during an open channel. Off-line programs perform standard analyses, and further processing can be performed with standard spreadsheet programs.
Additional Information
© 1985 Published by Elsevier. Received 17 October 1984, Revised 22 November 1984, Accepted 23 November 1984. We thank Mr. Michael Walsh in Caltech's Biology Electronics Shop for designing and building the window discriminator and the timeshare circuit. We thank Alison M. Gurney, Jeanne M. Nerbonne, Lee D. Chabala, Alan Finkel, Michael M. White, and Jerome Pine for testing and advising on the system. This research was sponsored by the National Institutes of Health (NS-11756).Additional details
- Eprint ID
- 105997
- Resolver ID
- CaltechAUTHORS:20201012-152226500
- NS-11756
- NIH
- Created
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2020-10-12Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field