Published April 2013
| Published
Journal Article
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Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant
- Creators
- Earnshaw, W. C.
- Allshire, R. C.
- Black, B. E.
- Bloom, K.
- Brinkley, B. R.
- Brown, W.
- Cheeseman, I. M.
- Choo, K. H. A.
- Copenhaver, G. P.
- DeLuca, J. G.
- Desai, A.
- Diekmann, S.
- Erhardt, S.
- Fitzgerald-Hayes, M.
- Foltz, D.
- Fukagawa, T.
- Gassmann, R.
- Gerlich, D. W.
-
Glover, D. M.
- Gorbsky, G. J.
- Harrison, S. C.
- Heun, P.
- Hirota, T.
- Jansen, L. E. T.
- Karpen, G.
- Kops, G. J. P. L.
- Lampson, M. A.
- Lens, S. M.
- Losada, A.
- Luger, K.
- Maiato, H.
- Maddox, P. S.
- Margolis, R. L.
- Masumoto, H.
- McAinsh, A. D.
- Mellone, B. G.
- Meraldi, P.
- Musacchio, A.
- Oegema, K.
- O'Neill, R. J.
- Salmon, E. D.
- Scott, K. C.
- Straight, A. F.
- Stukenberg, P. T.
- Sullivan, B. A.
- Sullivan, K. F.
- Sunkel, C. E.
- Swedlow, J. R.
- Walczak, C. E.
- Warburton, P. E.
- Westermann, S.
- Willard, H. F.
- Wordeman, L.
- Yanagida, M.
- Yen, T. J.
- Yoda, K.
- Cleveland, D. W.
Abstract
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
Additional Information
© The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Received: 15 March 2013 / Revised: 17 March 2013 / Accepted: 17 March 2013 / Published online: 12 April 2013. WCE and RCA are Principal Reseach Fellows of the Wellcome Trust [grant numbers 073915 and 095021, respectively]. The Wellcome Trust Centre for Cell Biology is supported by core grant numbers 077707 and 092076. BEB is funded by NIH R01-GM082989, a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund and a Rita Allen Foundation Scholar Award. KB is funded by grant R37 GM32238. IMC is funded by NIH grant GM088313. DWC is an Investigator of the Ludwig Institute, whose centromere work is supported by NIH grant GM074150. GPC thanks the National Science Foundation (MCB-1121563) for support. JGD is supported by NIH R01GM088371. TF is supported by the Cabinet Office, Government of Japan, through its 'Funding Program for Next Generation World-Leading Researchers'(LS122). RG is funded by an EMBO Installation Grant. DWG is funded by the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreements no. 241548 (MitoSys) and no. 258068 (Systems Microscopy) and from an ERC Starting Grant (no. 281198). DMG is supported by Cancer Research UK and the MRC. GJG is funded by NIH/NIGMS R01-50412, the Oklahoma Center for Advancement of Science and Technology and the McCasland Foundation. PH is funded by Seventh Framework Programme grant BioSynCen from the European Research Council. TH is funded by Research Grants from the Japanese Society for the Promotion of Science (JSPS) and the Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT). LETJ is funded by FCT grants BIA-BCM/100557/2008, BIAPRO/100537/2008 and an EMBO installation grant. GK is funded by NIH grant 5R01GM61169, GJPLK is supported by grants from the ERC (KINSIGN) and the Netherlands Organisation for Scientific Research (NWO-Vici-016.130.661). MAL is funded by NIH grant GM083988. SML is supported by grants from the Dutch Cancer Society (UU2009-4311, UU2011-5134) and the Netherlands Organisation for Scientific Research (NWO-Vici-91812610). AL is supported by the Spanish Ministry of Economy (grants CSD2007-015 and SAF2010-25157) and the EU (Marie Curie ITN "Nucleosome 4D"). HM is funded by grants PTDC/SAU-GMG/099704/2008 and PTDC/SAU-ONC/112917/2009 from FCT (COMPETE-FEDER), the Human Frontier Science Program and the 7th framework program grant PRECISE from the European Research Council. ADM is funded by BBSRC grant (BB/I021353/1). RLM is funded by NIH grant R01GM088716. HM is supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and the Kazusa DNA Research Institute Foundation. PSM is supported by a grant from the CCSRI (700824). BGM is funded by NSF award number 1024973. PM is funded by the Swiss National Foundation, University of Geneva and the Foundation Louis-Jeantet. RJO is supported by the NSF. EDS is funded by NIH grant R37GM024364. AFS is funded by NIH grant R01GM074728. PTS is funded by NIH grant number-R01 GM063045. BS is funded by NIH R01 GM098500 and March of Dimes 6-FY10-294. KFS is funded by Science Foundation Ireland grant 12/IA/1370. CES is funded by grants from the Fundação para Ciência e Tecnologia of Portugal, COMPETE and ON2. JRS is funded by BBSRC grant BB/H013024. CEW is funded by NIH grant GM059618. LW is funded by NIH grant GM69429. TY is funded by NIH grant GM083988, Core Grant CA06927, and an appropriation from the Commonwealth of Pennsylvania.Attached Files
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Additional details
- PMCID
- PMC3627038
- Eprint ID
- 105878
- Resolver ID
- CaltechAUTHORS:20201007-123358388
- 073915
- Wellcome Trust
- 095021
- Wellcome Trust
- 077707
- Wellcome Trust
- 092076
- Wellcome Trust
- R01-GM082989
- NIH
- Burroughs Wellcome Fund
- Rita Allen Foundation
- R37 GM32238
- NIH
- GM088313
- NIH
- Ludwig Institute
- GM074150
- NIH
- MCB-1121563
- NSF
- R01GM088371
- NIH
- LS122
- Cabinet Office, Government of Japan
- European Molecular Biology Organization (EMBO)
- 241548
- European Research Council (ERC)
- 258068
- European Research Council (ERC)
- 281198
- European Research Council (ERC)
- Cancer Research UK
- Medical Research Council (UK)
- R01-50412
- NIH
- Oklahoma Center for Advancement of Science and Technology
- McCasland Foundation
- Japan Society for the Promotion of Science (JSPS)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- BIA-BCM/100557/2008
- Fundação para a Ciência e a Tecnologia (FCT)
- BIAPRO/100537/2008
- Fundação para a Ciência e a Tecnologia (FCT)
- 5R01GM61169
- NIH
- NWO-Vici-016.130.661
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
- GM083988
- NIH
- UU2009-4311
- Dutch Cancer Society
- UU2011-5134
- Dutch Cancer Society
- NWO-Vici-91812610
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
- CSD2007-015
- Ministerio de Economía, Industria y Competitividad (MINECO)
- SAF2010-25157
- Ministerio de Economía, Industria y Competitividad (MINECO)
- Marie Curie Fellowship
- PTDC/SAU-GMG/099704/2008
- Fundação para a Ciência e a Tecnologia (FCT)
- PTDC/SAU-ONC/112917/2009
- Fundação para a Ciência e a Tecnologia (FCT)
- Fondo Europeo de Desarrollo Regional (FEDER)
- Human Frontier Science Program
- BB/I021353/1
- Biotechnology and Biological Sciences Research Council (BBSRC)
- R01GM088716
- NIH
- Kazusa DNA Research Institute Foundation
- 700824
- Canadian Cancer Society Research Institute
- MCB-1024973
- NSF
- Swiss National Science Foundation (SNSF)
- University of Geneva
- Foundation Louis-Jeantet
- R37GM024364
- NIH
- R01GM074728
- NIH
- R01 GM063045
- NIH
- R01 GM098500
- NIH
- 6-FY10-294
- March of Dimes
- 12/IA/1370
- Science Foundation, Ireland
- BB/H013024
- Biotechnology and Biological Sciences Research Council (BBSRC)
- GM059618
- NIH
- GM69429
- NIH
- GM083988
- NIH
- CA06927
- NIH
- Commonwealth of Pennsylvania
- COMPETE
- Fundação para a Ciência e a Tecnologia (FCT)
- ON2
- Fundação para a Ciência e a Tecnologia (FCT)
- Created
-
2020-10-08Created from EPrint's datestamp field
- Updated
-
2023-03-16Created from EPrint's last_modified field