Polo kinase: the choreographer of the mitotic stage?
Abstract
The regulation of protein function through phosphorylation is fundamental in controlling cell cycle progression. To date, most attention has focused on the cyclin-dependent protein kinases (cdks) 1 (for review see reference 21). However, whereas the p34^(cdc)-cyclin B complex appears to regulate the mitotic "state" and in this way changes the overall organization of the cell, members of another conserved serine/threonine kinase family appears to be able to control the dynamics of cellular architecture. These are the polo-like kinases (plks) which orchestrate several mitotic events including the formation of the bipolar spindle, and at least in some organisms, the process of cytokinesis. It appears that in some of its roles the plk cooperates with p34^(cdc2) and indeed recent work (15) has suggested that one plk can help maintain the mitotic state by phosphorylating the cdc25 phosphatase that activates p34^(cdc2).
Additional Information
© The Rockefeller University Press 1996. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode, or updates thereof. Received for publication 16 October 1996 and in revised form 14 November 1996. We apologize to authors whose work we have not cited due to space constraints. Work on plks in the authors' laboratory is supported by grants from the Cancer Research Campaign, the BBSRC, and the European Union.Attached Files
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Additional details
- PMCID
- PMC2133943
- Eprint ID
- 105824
- Resolver ID
- CaltechAUTHORS:20201005-153617012
- Cancer Research Campaign
- Biotechnology and Biological Sciences Research Council (BBSRC)
- European Union
- Created
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2020-10-06Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field