Published July 1, 2003
| Published
Journal Article
Open
giant nucleiis essential in the cell cycle transition from meiosis to mitosis
Chicago
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Abstract
At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.
Additional Information
© 2003 The Company of Biologists Ltd. Accepted 14 March 2003. This work was initiated in the Department of Biochemistry, Imperial College London, continued at the University of Dundee, before being brought to its present conclusion in the Zoology Department at Oxford. We are extremely grateful to the Cancer Research Campaign (now Cancer Research UK) for Core Programme support to D.M.G. and Project Grant support to J.M.A. D.M.G. and R.D.C.S. also received Medical Research Council (MRC) Project Grant support when at Imperial College, and X.-H.Z., J.M.A. and L.S.A. are currently members of an MRC Co-operative Group (with MRC Project Grant support to J.M.A.) in Oxford. During the course of this work, L.M.F. received a support to study for the PhD degree of the University of Dundee from the Science and Engineering Research Council, now long metamorphosed into the Biotechnology and Biological Sciences Research Council. A.D.R. was supported by the States of Jersey for DPhil studies at the University of Oxford. We would like to thank Pernille Rørth for the UASp vector; Adelaide Carpenter, Peter Duchek, János Gausz, Terry Orr-Weaver, Daniel St. Johnston, Bloomington and Tübingen stock centres for fly stocks; Ruth Lehmann and Helen White-Cooper for help and advice; and Balázs Szöór for the I-2Dm protein.Attached Files
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Additional details
- Eprint ID
- 105763
- Resolver ID
- CaltechAUTHORS:20201002-140639974
- Cancer Research Campaign
- Cancer Research UK
- Medical Research Council (UK)
- Science and Engineering Research Council (SERC)
- Biotechnology and Biological Sciences Research Council (BBSRC)
- States of Jersey
- Created
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2020-10-05Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field