Published October 2003
| public
Journal Article
Aurora A on the Mitotic Spindle Is Activated by the Way It Holds Its Partner
- Creators
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Glover, David M.
Abstract
An exciting study in this issue (Bayliss et al., 2003) reveals how binding of the microtubule associated protein TPX2 to the mitotic kinase Aurora A induces a conformational change. This moves the phosphorylated activation domain into a more compact position within the kinase core, providing a better substrate binding platform and hiding the activating phosphoryl group from attack by PP1.
Additional Information
© 2003 Cell Press. Under an Elsevier user license.Additional details
- Eprint ID
- 105614
- DOI
- 10.1016/s1097-2765(03)00405-2
- Resolver ID
- CaltechAUTHORS:20200928-150626522
- Created
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2020-09-29Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field