Tumor Necrosis Factor:A Potent Mediator of Macrophage-Dependent Tumor-Cell Killing
Abstract
Macrophages (Mφ) can be activated to show highly selective cytotoxicity toward malignant cells in vitro [6, 8, 9, 13, 14] and there is some evidence that they may destroy neoplastic cells in vivo [1]. The importance of activated Mφ (aMφ) in controlling tumor growth in vivo has been further implicated in experiments involving murine ultraviolet light (UV)-induced tumors, which are highly immunogenic regressor tumors [10] sensitive to Mφ in vitro [22]. Variants of these tumors demonstrating progressive growth in the normal host were found to invariably express an increased resistance to aMφ [22]. Furthermore, exposure of regressor tumor cells to aMφ in vitro also resulted in selection for Mφ-resistant cancer cells which displayed an increased early growth potential in vivo [22]. More recently we have utilized these tumor variants resistant to aMφ to explore the mechanism by which aMφ induce tumor cell destruction [23].
Additional Information
© 1987 Springer-Verlag Berlin Heidelberg. This work was supported by grants CA-22677, CA-19266, CA-37156, 5-T32 AI-07090, and 5-T32 GMO-7281 from the National Institutes of Health.Additional details
- Eprint ID
- 105532
- Resolver ID
- CaltechAUTHORS:20200924-154443392
- CA-22677
- NIH
- CA-19266
- NIH
- CA-37156
- NIH
- 5-T32 AI-07090
- NIH Predoctoral Fellowship
- 5-T32 GMO-7281
- NIH Predoctoral Fellowship
- Created
-
2020-09-24Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Series Name
- Haematology and Blood Transfusion / Hämatologie und Bluttransfusion
- Series Volume or Issue Number
- 31