Published December 2020
| public
Journal Article
Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective
Abstract
Despite the peripheral nervous system's (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors and synthetic neural scaffold technology hold promise in augmenting endogenous PNS regeneration following PNI. Clinical trials utilizing neurotrophic factors for other indications (eg, peripheral neuropathy) may provide insight into their role in PNI. Here we provide an updated review of progress made towards enhancing regeneration after PNI with a focus on neurotrophic factors and bioengineered scaffolds.
Additional Information
© 2020 Peripheral Nerve Society. Accepted manuscript online: 16 September 2020. Manuscript accepted: 07 September 2020. Manuscript revised: 05 September 2020. Manuscript received: 15 August 2020.Additional details
- Eprint ID
- 105521
- Resolver ID
- CaltechAUTHORS:20200924-144350749
- Created
-
2020-09-25Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field