Coronavirus Disease 2019 Patients in Earlier Stages Exhaled Millions of Severe Acute Respiratory Syndrome Coronavirus 2 Per Hour

Creators: Ma, Jianxin; Qi, Xiao; Chen, Haoxuan; Li, Xinyue; Zhang, Zheng; Wang, Haibin; Sun, Lingli; Zhang, Lu; Guo, Jiazhen; Morawska, Lidia; Grinshpun, Sergey A.; Biswas, Pratim; Flagan, Richard C.; Yao, Maosheng

Abstract

Coronavirus disease 2019 (COVID-19) patients exhaled millions of severe acute respiratory syndrome coronavirus 2 RNA copies per hour, which plays an important role in COVID-19 transmission. Exhaled breath had a higher positive rate (26.9%, n = 52) than surface (5.4%, n = 242) and air (3.8%, n = 26) samples.

Additional Information

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model). Received: 15 July 2020; Editorial decision: 24 August 2020; Accepted: 26 August 2020; Published: 28 August 2020; Corrected and typeset: 08 October 2020. The authors thank the local Center for Disease Prevention and Control medical stuff for their assistance in recruiting patients. This research was supported by the National Natural Science Foundation of China (NSFC; 22040101) and the NSFC Distinguished Young Scholars Fund (21725701 to M. Y.). Author contributions. M. Y. and J. M. contributed to the study design. J. M., M. Y., X. Q., Z. Z., H. W., L. S., and J. G. contributed to sample collection and experiments. J. M., X. Q., and M. Y. contributed to patients' recruitment and clinical management. M. Y., J. M., X. L., H. C., L. Z., L. M., S. A. G., P. B., and R. C. F. contributed to data analysis, data interpretation, figure preparation, and literature search. M. Y. wrote the manuscript draft, and all authors revised the manuscript. All authors reviewed and approved the final version of the report. Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.

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