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Published February 2003 | public
Journal Article

The Scaling of White Matter to Gray Matter in Cerebellum and Neocortex

Abstract

It is known that the white matter of neocortex increases disproportionately with brain size. However, relatively few measurements have been made of white matter/gray matter scaling in the cerebellum. We present data on the volumes of white and gray matter in both structures, taken from 45 species of mammals. We find a scaling exponent of 1.13 for cerebellum and 1.28 for neocortex. The 95% confidence intervals for our estimates of these two exponents do not overlap. This difference likely reflects differences in the connectivity and/or micro-structure of white matter in the two regions.

Additional Information

© 2003 S. Karger AG, Basel. Received: October 3, 2002. Returned for revision: November 1, 2002. Accepted after revision: November 26, 2002. We would like to thank Wally Welker, who provided access to the Wisconsin brain collection, as well as Inge Siggelkow for assistance there. We would also like to thank Sam Wang for several stimulating discussions and for comments and suggestions on a draft of this paper. This work was supported by NIH EY11759 and NIH GM07737.

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023