Gi Irks GIRKs

Abstract

G protein-activated potassium channels (GIRKs), monitored with the temporal and molecular resolution of electrophysiology, play a key role in the study of signal transduction. GIRKs are activated primarily by the Gβγ subunits, but a paper by Peleg et al. (2002)([this issue of Neuron]) demonstrates a role for Gα subunits in suppressing basal activity and supports the idea of a macromolecular complex of G protein, GIRK, and perhaps RGS protein.

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