Epithelial-to-mesenchymal transition and different migration strategies as viewed from the neural crest
Abstract
Epithelial-to-mesenchymal transition (EMT) is a dynamic process that produces migratory cells from epithelial precursors. However, EMT is not binary; rather it results in migratory cells which adopt diverse strategies including collective and individual cell migration to arrive at target destinations. Of the many embryonic cells that undergo EMT, the vertebrate neural crest is a particularly good example which has provided valuable insight into these processes. Neural crest cells from different species often adopt different migratory strategies with collective migration predominating in anamniotes, whereas individual cell migration is more prevalent in amniotes. Here, we will provide a perspective on recent work toward understanding the process of neural crest EMT focusing on how these cells undergo collective and individual cell migration.
Additional Information
© 2020 Elsevier Ltd. Available online 9 June 2020. This review comes from a themed issue on Cell Dynamics; Edited by Diane Barber and Xavier Trepat. The authors would like to acknowledge Dr. Erica Hutchins for valuable discussion. This work was supported by the National Institutes of Health (K99DE029240 to M.L.P., R01DE027538 and R01DE027568 to M.E.B.). The authors apologize to those authors they were unable to cite because of space limitations. Conflict of interest statement: Nothing declared.Additional details
- Eprint ID
- 103799
- DOI
- 10.1016/j.ceb.2020.05.001
- Resolver ID
- CaltechAUTHORS:20200609-133046051
- K99DE029240
- NIH
- R01DE027538
- NIH
- R01DE027568
- NIH
- Created
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2020-06-09Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering