A data resource from concurrent intracranial stimulation and functional MRI of the human brain
Abstract
Mapping the causal effects of one brain region on another is a challenging problem in neuroscience that we approached through invasive direct manipulation of brain function together with concurrent whole-brain measurement of the effects produced. Here we establish a unique resource and present data from 26 human patients who underwent electrical stimulation during functional magnetic resonance imaging (es-fMRI). The patients had medically refractory epilepsy requiring surgically implanted intracranial electrodes in cortical and subcortical locations. One or multiple contacts on these electrodes were stimulated while simultaneously recording BOLD-fMRI activity in a block design. Multiple runs exist for patients with different stimulation sites. We describe the resource, data collection process, preprocessing using the fMRIPrep analysis pipeline and management of artifacts, and provide end-user analyses to visualize distal brain activation produced by site-specific electrical stimulation. The data are organized according to the brain imaging data structure (BIDS) specification, and are available for analysis or future dataset contributions on openneuro.org including both raw and preprocessed data.
Additional Information
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files associated with this article. Received 20 May 2020; Accepted 03 July 2020; Published 05 August 2020. Funded by NIH grant U01NS103780 (RP, RA and MH), The Simons Foundation Collaboration on the Global Brain (RA), Knut and Alice Wallenberg Foundation grant 2016.0473 (WHT), National Health and Medical Research Council grant 1156536 (JMS) and UK Wellcome Trust (CIP) and European Research Council (CIP). The OpenNeuro repository is funded by NIH Grant R24MH117179 (RP). Open access funding provided by Karolinska Institute. Code availability: See https://github.com/wiheto/esfmri_data_descriptor for code used for: fMRIPrep execution, MRIQC comparision, and confound differences between pre and postop. Author Contributions: These authors contributed equally: W. H. Thompson, R. Nair, H. Oya. Conception and design of the work: H.O., M.H., R.A. and C.I.P. Data collection: H.O. and M.H. Data curation: H.O. and R.N. Data preprocessing, analysis, verification and/or quality control: W.H.T., R.N. and O.E. Writing (initial draft): W.H.T., R.N., H.O., and R.A. Writing (revising draft): W.H.T., R.N., H.O., O.E., C.I.P., J.M.S. and R.A. The authors declare no competing interests.Attached Files
Published - s41597-020-00595-y.pdf
Submitted - 2020.05.18.102657v3.full.pdf
Supplemental Material - media-1.pdf
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Additional details
- Alternative title
- Human es-fMRI Resource: Concurrent deep-brain stimulation and whole-brain functional MRI
- PMCID
- PMC7406507
- Eprint ID
- 103372
- Resolver ID
- CaltechAUTHORS:20200521-070132863
- U01NS103780
- NIH
- Simons Foundation
- 2016.0473
- Knut and Alice Wallenberg Foundation
- 1156536
- National Health and Medical Research Council
- Wellcome Trust
- European Research Council (ERC)
- R24MH117179
- NIH
- Karolinska Institute
- Created
-
2020-05-21Created from EPrint's datestamp field
- Updated
-
2023-06-01Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering