Published January 1993
| public
Journal Article
Signalling through SH2 and SH3 domains
- Creators
- Mayer, Bruce J.
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Baltimore, David
Abstract
In 1986, Pawson's group recognized a region of homology between two oncogenic tyrosine kinases that lay outside the catalytic domain. They termed this the Src homology 2, or SH2, domain. In the ensuing years, SH2 domains have been found in an impressive variety of proteins, as has a second region of homology, inevitably termed SH3. These domains appear to mediate controlled protein-protein interactions. Many proteins that contain SH2 and SH3 domains are involved in signal transduction, suggesting a new paradigm for regulation of intracellular signalling pathways.
Additional Information
© 1993 Elsevier Science Publishers Ltd. We thank A. Bender, D. Cowburn, J. Darnell, I. Kuriyan, T. Pawson and I. Schlessinger for helpful discussions and for communicating unpublished results, and T. Fujita for critically reading this manuscript. We are especially grateful to G. Waksman for preparing Fig. 2.Additional details
- Eprint ID
- 103190
- DOI
- 10.1016/0962-8924(93)90194-6
- Resolver ID
- CaltechAUTHORS:20200513-152803250
- Created
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2020-05-13Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field