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Published May 1, 2020 | public
Journal Article

Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits

Abstract

Existing treatments for brain disorders aim to modulate the activity of neural circuits, but are either not cell type-specific, lack spatial targeting, or require invasive procedures. Previously, we introduced an approach to modulating neural circuits noninvasively with spatial, cell-type, and temporal specificity called acoustically targeted chemogenetics, or ATAC. We use ultrasound to open the blood brain barrier to transduce neurons at specific locations in the brain with virally-encoded chemogenetic receptors. To show neuronal inhibition expressed inhibitory DREADD (hM4Di) throughout the hippocampus and tested mice in a fear conditioning protocol. The context fear test showed that mice treated with saline froze significantly more than those who had received CNO (p<2E-5, n=7,11) during the training phase.

Additional Information

© 2020 Published by Elsevier Inc. Supported By: NARSAD, Jacobs Institute for Molecular Engineering for Medicine, DARPA.

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023