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Published September 2003 | public
Journal Article

Coupling Cell Growth, Proliferation, and Death: Hippo Weighs In

Abstract

Four recent papers describe the characterization in Drosophila of Hippo, a serine/threonine kinase of the Sterile 20 (STE20) group, resembling Mst1 and Mst2. Hippo restricts cell growth and cell proliferation, promotes cell death, and interacts with the tumor suppressors Salvador and Warts. This, together with the ability of Mst2 to rescue hippo mutant phenotypes, argues that Mst/Hippo proteins are tumor suppressors.

Additional Information

© 2003 Cell Press. Available online 11 September 2003.

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023