Published February 2020
| public
Journal Article
Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives
- Creators
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Zhu, Meng
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Zernicka-Goetz, Magdalena
Abstract
Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establish cell polarization. In this review, we discuss the current understanding of cell polarity establishment, focusing on the formation of the apical domain in the mouse embryo. We will also discuss outstanding questions and possible directions for future study.
Additional Information
© 2019 Elsevier. Available online 21 December 2019. This review comes from a themed issue on Cell architecture; Edited by Sandrine Etienne-Manneville and Robert Arkowitz. We thank Christos Kyprianou and Hannah Mudge for their feedback on the manuscript. M.Z.G receives funding from Wellcome Trust, ERC, and Leverhulme Trust. M.Z is funded by Leverhulme Trust. Conflict of interest statement: Nothing declared.Additional details
- Eprint ID
- 102440
- DOI
- 10.1016/j.ceb.2019.11.005
- Resolver ID
- CaltechAUTHORS:20200409-115737960
- Wellcome Trust
- Leverhulme Trust
- European Research Council (ERC)
- Created
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2020-04-09Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering