Published April 6, 2020
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Decrease in ACE2 mRNA expression in aged mouse lung
- Creators
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Booeshaghi, A. Sina
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Pachter, Lior
Abstract
Angiotensin-converting enzyme 2 (ACE2) has been identified as a critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to extensive speculation on the role of ACE2 in disease severity, and in particular, whether variation in its expression can explain higher mortality in older individuals. We examine this question in mouse lung and show that 24-month old mice have significantly reduced ACE2 mRNA expression relative to 3-month old mice. The differences appear to be localized to ciliated cells.
Additional Information
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. Posted April 05, 2020. Data availability: Raw FASTQ files can be obtained from GSE124872.Attached Files
Submitted - 2020.04.02.021451v1.full.pdf
Supplemental Material - media-1.pdf
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Additional details
- Eprint ID
- 102345
- Resolver ID
- CaltechAUTHORS:20200406-101324270
- Created
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2020-04-06Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field
- Caltech groups
- COVID-19, Division of Biology and Biological Engineering