Published February 17, 2020
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Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo
Abstract
Tremendous progress in synthetic micro/nanomotors has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo. Here, we present a photoacoustic computed tomography (PACT) guided investigation of micromotors in intestines in vivo. The micromotors enveloped in microcapsules exhibit efficient propulsion in various biofluids once released. PACT has visualized the migration of micromotor capsules toward the targeted regions in real time in vivo. The integration of the developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo.
Additional Information
© 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored by the Startup funds from California Institute of Technology (to W.G.) and the NIH grants EB016986 (NIH Director's Pioneer Award), CA186567 (NIH Director's Transformative Research Award), NS090579, and NS099717 (all to L.V.W.). We gratefully acknowledge critical support and infrastructure provided for this work by the Kavli Nanoscience Institute at Caltech.Attached Files
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Additional details
- Eprint ID
- 101427
- Resolver ID
- CaltechAUTHORS:20200220-134102759
- Caltech
- DP1 EB016986
- NIH
- CA186567
- NIH
- NS090579
- NIH
- NS099717
- NIH
- Created
-
2020-02-20Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Caltech groups
- Kavli Nanoscience Institute
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 11240