Published April 2020
| Accepted Version
Journal Article
Open
Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes
- Creators
-
Mobbs, George W.
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Hoelz, André
Abstract
Oocytes stockpile nuclear pore complexes (NPCs) in cytoplasmic membrane sheets called annulate lamellae (AL) in preparation for rapid cell cycles during embryogenesis. Recently, Hampoelz et al. reported that AL–NPC assembly depends on the coordinated formation, transport, and interaction of biomolecular condensates containing distinct sets of nucleoporins.
Additional Information
© 2020 Elsevier Ltd. Available online 13 February 2020. We thank Alina Patke for help with editing of the manuscript and figure preparation. A.H. is an Investigator of the Heritage Medical Research Institute and a Faculty Scholar of the Howard Hughes Medical Institute and was supported by National Institutes of Health grants R01-GM111461 and R01-GM117360.Attached Files
Accepted Version - nihms-1629252.pdf
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Additional details
- Alternative title
- Nucleoporin Condensates Drive NPC Assembly in Oocytes
- PMCID
- PMC7505689
- Eprint ID
- 101264
- DOI
- 10.1016/j.tibs.2020.01.009
- Resolver ID
- CaltechAUTHORS:20200213-082709014
- Heritage Medical Research Institute
- Howard Hughes Medical Institute (HHMI)
- R01-GM111461
- NIH
- R01-GM117360
- NIH
- Created
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2020-02-13Created from EPrint's datestamp field
- Updated
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2022-02-15Created from EPrint's last_modified field
- Caltech groups
- Heritage Medical Research Institute