Functional Architecture of Motion Direction in the Mouse Superior Colliculus
- Creators
- Li, Ya-tang
- Turan, Zeynep
- Meister, Markus
Abstract
Motion vision is important in guiding animal behavior. Both the retina and the visual cortex process object motion in largely unbiased fashion: all directions are represented at all locations in the visual field. We investigate motion processing in the superior colliculus of the awake mouse by optically recording neural responses across both hemispheres. Within the retinotopic map, one finds large regions of ∼500 μm size where neurons prefer the same direction of motion. This preference is maintained in depth to ∼350 μm. The scale of these patches, ∼30 degrees of visual angle, is much coarser than the animal's visual resolution (∼2 degrees). A global map of motion direction shows approximate symmetry between the left and right hemispheres and a net bias for upward-nasal motion in the upper visual field.
Additional Information
© 2020 Elsevier Inc. Received 9 December 2019, Revised 12 April 2020, Accepted 5 June 2020, Available online 10 July 2020. M.M. was supported by grants from NIH (R01 NS111477) and from the Simons Foundation (543015SPI). Y.-t.L was supported by a grant from the NEI (K99EY028640) and a Helen Hay Whitney Postdoctoral Fellowship. Author Contributions: Y.-t.L designed the study, performed all experiments, interpreted results, and wrote the manuscript. Z.T. provided partial-cortex mutant mice and validated their brain anatomy. M.M. helped design the study, interpret results, and write the manuscript. The authors declare no competing interests.Attached Files
Accepted Version - nihms-1708240.pdf
Submitted - 825711.full.pdf
Supplemental Material - 1-s2.0-S0960982220308393-mmc1.pdf
Files
Additional details
- PMCID
- PMC8221388
- Eprint ID
- 99595
- Resolver ID
- CaltechAUTHORS:20191031-141639740
- R01 NS111477
- NIH
- 543015SPI
- Simons Foundation
- K99EY028640
- NIH
- Helen Hay Whitney Foundation
- Created
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2019-10-31Created from EPrint's datestamp field
- Updated
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2023-07-17Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering