Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse

Creators: Fisher, Douglas A.; Hunt, Stephen W., III; Hood, Leroy

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Abstract

We have determined the DNA sequence of a gene encoding a thymus leukemia (TL) antigen in the BALB/c mouse, and have more definitively mapped the cloned BALB/c Tla-region class I gene clusters. Analysis of the sequence shows that the Tla gene is less closely related to the H-2 genes than H-2 genes are to one another or to a Qa-2,3-region genes. The Tla gene, 17.3A, contains an apparent gene conversion. Comparison of the BALB/c Tla genes with those from C57BL shows that BALB/c has more Tla-region class I genes, and that one of the genes absent in C57BL is gene 17.3A.

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© 1985 Rockefeller University Press. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode, or updates thereof. Received for publication 4 April 1985. This work was supported by grants from the National Institutes of Health, Bethesda, MD. S. Hunt is a Leukemia Society postdoctoral fellow. We thank K. Minard and D. Maloney for expert technical assistance, and C. Katz for preparation of the manuscript. The authors are grateful to J. Siu and Drs. E. Rothenberg, M. Kronenberg, I. Stroynowski, and N. Costlow for helpful comments on the manuscript.

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