Published December 2002
| public
Journal Article
The Effects of Structure on Gene Delivery with Linear β- and γ-Cyclodextrin-Containing Polycations
Abstract
Cyclodextrin (CD)-containing polycations are prepared bycopolymerization of3^A3^B-dideoxy-3^A,3^B-diamino-β- and γ-CDs with dimethyl suberimidate·2HCl to yieldpolyamidine products. Both alkyl- and alkoxy-diamines are used to vary the spacing between the CDand the amidine charge centers. It is found that the transfection efficiency andtoxicity of such polycations is dramatically affected by the structure of the spacer separatingthe CD ring from the charge centers and less so by the type of CD used.
Additional Information
© 2002 Kluwer Academic Publishers. Received: 7 May 2002; in final form: 1 October 2002. S.R.P. thanks the Department of Defense for an NDSEG fellowship. We would also like to thank Insert Therapeutics Inc. for partial support of this project. M.E.D. is a consultant to and has financial interest in Insert Therapeutics Inc.Additional details
- Eprint ID
- 99281
- DOI
- 10.1023/a:1023084322759
- Resolver ID
- CaltechAUTHORS:20191015-143301005
- National Defense Science and Engineering Graduate (NDSEG) Fellowship
- Created
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2019-10-15Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field