Human Antibody Genes: Evolutionary and Molecular Genetic Perspectives
- Creators
- Ellison, Jay W.
-
Hood, Leroy E.
- Others:
- Harris, Harry
- Hirschhorn, Kurt
Abstract
During the past several years a vast amount of information has been accumulated regarding the genes encoding immunoglobulin (Ig) molecules. Studies in the murine system have shown that the expression of these genes in lymphocytes involves a number of genetic processes, including DNA rearrangements, alternative patterns of RNA splicing, and somatic mutation, all of which serve to amplify the information encoded in the germ line. The cloning of mouse Ig genes has been facilitated by the availability of inducible myeloma tumors, which produce large quantities of homogeneous immunoglobulins (Potter, 1972). These myeloma tumors represent clonal cell populations that have undergone the DNA rearrangements necessary for antibody gene expression, and have furnished large amounts of Ig mRNA, which has served as the starting material for the isolation of the corresponding genes.
Additional Information
© 1983 Plenum Press, New York. We thank Bernita Larsh and Connie Katz for the preparation of the manuscript, and Ellen Kraig and Roger Perlmutter for their comments. This work was supported by a grant from the National Institutes of Health and by a National Research Award (1 T32 GM07616) to one of the authors (JE) from the National Institute of General Medical Sciences.Additional details
- Eprint ID
- 99232
- Resolver ID
- CaltechAUTHORS:20191011-074306600
- 1 T32 GM07616
- NIH Predoctoral Fellowship
- National Institute of General Medical Sciences
- Created
-
2019-10-11Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Series Name
- Advances in Human Genetics
- Series Volume or Issue Number
- 13