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Published October 2019 | public
Journal Article

Chlorate's Potential as a Pro-Drug for Killing Antibiotic-Tolerant Pathogens in the Cystic Fibrosis Lung

Abstract

Chronic lung infections are a major contributor to morbidity and mortality in cystic fibrosis (CF) patients. Perhaps the most notorious CF pathogen is Pseudomonas aeruginosa, which establishes decades-long lung infections despite aggressive antibiotic treatment. In part, drugs fail to clear P. aeruginosa lung infections because some pathogen populations exhibit antibiotic tolerance, a metabolic state that reduces a cell's susceptibility to drugs. Antibiotic tolerance is associated with low metabolic activity, and P. aeruginosa growth is limited by oxygen availability in the largely hypoxic/anoxic CF sputum.

Additional Information

© 2019 Wiley Periodicals, Inc. First published: 05 September 2019.

Additional details

Created:
August 22, 2023
Modified:
October 18, 2023