Published October 2019
| public
Journal Article
Nontuberculous Mycobacterial Aggregation is Regulated by C:N Balance
- Creators
- DePas, W.
- Bergkessel, M.
- Newman, D. K.
Abstract
The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat, motivating studies to identify new therapeutic targets. Experiments using zebrafish and human cell culture lines have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, at least in part because of the decreased ability of phagocytes to efficiently engulf and kill corded M. abscessus cells.
Additional Information
© 2019 Wiley Periodicals, Inc. First published: 05 September 2019. Supported by the Cystic Fibrosis Foundation and the National Institutes of Health.Additional details
- Eprint ID
- 98873
- DOI
- 10.1002/ppul.22495
- Resolver ID
- CaltechAUTHORS:20190926-103130771
- Cystic Fibrosis Foundation
- NIH
- Created
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2019-09-26Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Caltech groups
- Division of Geological and Planetary Sciences