Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb
- Creators
- Sánchez-Guardado, Luis
- Lois, Carlos
Abstract
Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.
Additional Information
© 2019, Sanchez-Guardado & Lois. This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited. Received: 08 March 2019; Accepted: 26 August 2019; Published: 27 August 2019. Funding: NIH Office of the Director (RO1MH116508). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Ethics -- Animal experimentation: In all experiments, mice were handled according to the mice protocol (#1709) approved by the Institutional Animal Care and Use Committee (IACUC) of the California Institute of California. Reviewing Editor: Stephen Liberles, Harvard Medical School, United States. The authors declare that no competing interests exist.Attached Files
Published - elife-46675-v2.pdf
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Additional details
- PMCID
- PMC6744224
- Eprint ID
- 98396
- DOI
- 10.7554/elife.46675
- Resolver ID
- CaltechAUTHORS:20190903-130240956
- RO1MH116508
- NIH
- Created
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2019-09-03Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field