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Published June 2019 | public
Book Section - Chapter

Dual-Function Intravascular Catheter for Atherosclerosis Diagnostics

Abstract

We herein present a novel intravascular catheter, with dual-functions of electrical impedance spectroscopy (EIS) and flow fraction reserve (FFR), validated in live pig animal for atherosclerosis/plaques diagnostics. FFR has been the standard tool in determining plaque vulnerability yet could produce false negative results when stenosis is relatively small. Meanwhile, EIS has been demonstrated to specifically distinguish the lipid-rich pool, the signifying feature of rupture-prone plaques. The synergetic performance of these two functionalities can significantly enhance state-of-art diagnostics accuracy for atherosclerosis.

Additional Information

© 2019 IEEE. This study was supported by National Institutes of Health grants HL118650 (T.K.H., Y.C.T.), HL083015 (T.K.H.), HL111437 (T.K.H., Y.C.T.). The authors also want to thank colleagues from Caltech MEMS Lab and Cardiovascular Engineering Lab in UCLA for their kind help and fruitful discussion throughout this work.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023