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Published June 2019 | public
Book Section - Chapter

MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability

Abstract

This paper reports on the first MEMS silicon cutters designed to rapidly section donor pancreatic islets below oxygen diffusion-limited dimensions to improve viability of grafts during the critical period of re-implantation and revascularization by the host. The monolithic silicon chips feature an array of spaced nano-sharp (r < 100 nm) blades that cleanly section islet tissue. This work represents the first time that sectioning of pancreatic islets has been proposed and validated as a means to overcome the well-known problems of hypoxia and core-necrosis that is encountered in current islet transplantation procedures.

Additional Information

© 2019 IEEE. Thanks to members of the MEMS lab for their help with this work, notably Trevor Roper, Christine Garske, and Nicholas Scianmarello. We would also like to thank the Caltech-City of Hope Biomedical Research Initiative for funding this project.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023