Published May 27, 2019 | public
Journal Article

The role of the redox active 4Fe–4S cluster of yeast Dna2

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Abstract

Dna2 is an essential nuclease-helicase conserved throughout eukaryotic organisms with an impressive repertoire of DNA maintenance activity (Budd & Campbell, 1995). Due to its major roles in Okazaki fragment processing during DNA replication, double strand break repair, telomere maintenance and mitochondrial DNA maintenance, it is not surprising that both Dna2 upregulation and mutation have been observed in various types of cancer (Lee, Kim, Yoo, & Lee, 2010; Strauss, 2014).

Additional Information

© 2019 Taylor & Francis. Published online: 27 May 2019.

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Created:
August 19, 2023
Modified:
October 18, 2023