WormBase - Annotating many nematode genomes
Abstract
WormBase (www.wormbase.org) has been serving the scientific community for over 11 years as the central repository for genomic and genetic information for the soil nematode Caenorhabditis elegans. The resource has evolved from its beginnings as a database housing the genomic sequence and genetic and physical maps of a single species, and now represents the breadth and diversity of nematode research, currently serving genome sequence and annotation for around 20 nematodes. In this article, we focus on WormBase's role of genome sequence annotation, describing how we annotate and integrate data from a growing collection of nematode species and strains. We also review our approaches to sequence curation, and discuss the impact on annotation quality of large functional genomics projects such as modENCODE.
Additional Information
© 2012 Landes Bioscience. Submitted: 11/02/11; Revised: 02/02/12; Accepted: 02/02/12. This work is supported by the US National Institutes of Health (Grant no. P41 HG02223); US National Human Genome Research Institute (Grant no. P41-HG02223); and British Medical Research Council (Grant no. G070119); P.W.S. is an investigator with the Howard Hughes Medical Institute. Funding for open access charge: US National Human Genome Research Institute (Grant no. P41-HG02223).Attached Files
Published - worm-1-15.pdf
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Additional details
- PMCID
- PMC3670165
- Eprint ID
- 95463
- Resolver ID
- CaltechAUTHORS:20190514-075525922
- NIH
- P41 HG02223
- Medical Research Council (UK)
- G070119
- Howard Hughes Medical Institute (HHMI)
- Created
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2019-05-14Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field