Published March 2002
| public
Journal Article
Role of Double-Stranded RNA in Eukaryotic Gene Silencing
Abstract
Data on RNA interference, that is, posttranscriptional gene silencing by homologous double-stranded (ds) RNA, are reviewed. Gene silencing caused by exogenous dsRNA in artificial systems and observed in transgenic organisms carrying additional gene copies is considered. Data are summarized on the mechanism that arose during evolution of the Drosophila melanogaster genome to suppress repetitive genes with the use of dsRNA and thereby to prevent male sterility. The role of dsRNA in inhibiting expression and transposition of mobile elements is discussed on the basis of authors' own and published findings.
Additional Information
© 2002 MAIK "Nauka/Interperiodica". Translated from Molekulyarnaya Biologiya, Vol. 36, No. 2, 2002, pp. 240–251. Original Russian Text Copyright © 2002 by Aravin, Klenov, Vagin, Rozovskii, Gvozdev. Received October 10, 2001. This work was supported by the Russian Foundation for Basic Research (project nos. 99-04-48561, 01-04-48514, 00-15-97896, 01-04-06427, 01-04-06428) and the Russian program Frontiers in Genetics (project no. 99-1-069).Additional details
- Eprint ID
- 95441
- Resolver ID
- CaltechAUTHORS:20190513-134220628
- 99-04-48561
- Russian Foundation for Basic Research
- 01-04-48514
- Russian Foundation for Basic Research
- 00-15-97896
- Russian Foundation for Basic Research
- 01-04-06427
- Russian Foundation for Basic Research
- 01-04-06428
- Russian Foundation for Basic Research
- 99-1-069
- Russian Foundation for Basic Research
- Created
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2019-05-13Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field