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Published May 26, 2006 | Supplemental Material
Journal Article Open

Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing

Abstract

Order from chaos: Microfluidic chaotic mixing shows a significant improvement in the equilibration time of hybridization in DNA microarrays over conventional techniques. These results illustrate a new concept for performing kinetics studies in microfluidic devices.

Additional Information

© 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: October 29, 2005; Revised: February 16, 2006; Published online: April 26, 2006. This research was supported by the NIH Director's Pioneer Award (7DP1 0D000251-02) and NIH 1R01 HG002644-01A1. We thank Yanxia Hao and Dr. Christopher S. Baker of the Genomics Core Laboratory, Gladstone Institutes for providing mouse-printed oligoarrays (17 K) and Frederick Balagadde of Caltech for technical assistance.

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