Published December 2005
| public
Journal Article
Cleavage pattern and emerging asymmetry of the mouse embryo
- Creators
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Zernicka-Goetz, Magdalena
Abstract
Early mammalian development is regulative — it is flexible and responsive to experimental intervention. This flexibility could be explained if embryogenesis were originally completely unbiased and disordered; order and determination of cells only arising later. Alternatively, regulative behaviour could be consistent with the embryo having some order or bias from the very beginning, with inflexibility and cell determination increasing steadily over time. Recent evidence supports the second view and indicates that the sequence and the orientations of cell divisions help to build the first asymmetries.
Additional Information
© 2005 Nature Publishing Group. I am grateful for the contributions made by current and past collaborators and members of my laboratory and for support to my laboratory from the Wellcome Trust, Biotechnology and Biological Sciences Research Council (BBSRC) and European Molecular Biology Organization young investigator (EMBO YIP) award. I apologize to those whose work has gone unmentioned owing to space limitations. The author declares no competing financial interests.Additional details
- Eprint ID
- 94815
- DOI
- 10.1038/nrm1782
- Resolver ID
- CaltechAUTHORS:20190419-105737517
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (BBSRC)
- European Molecular Biology Organization (EMBO)
- Created
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2019-04-23Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field