Published August 2018
| public
Journal Article
Deconstructing and reconstructing the mouse and human early embryo
Abstract
The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
Additional Information
© 2018 Springer Nature Publishing AG. Received: 19 January 2018; Accepted: 15 June 2018; Published online: 23 July 2018. We apologize to our colleagues whose findings we could not cite due to space constraints. We are grateful to S.E. Harrison, M. Zhu, F. Antonica and M. Petruzzelli for their insightful comments. The M.Z-G lab is supported by grants from the European Research Council (669198) and the Wellcome Trust (098287/Z/12/Z). M. Shahbazi is supported by an Early Career Leverhulme Trust fellowship. The authors declare no competing interests.Additional details
- Eprint ID
- 94528
- Resolver ID
- CaltechAUTHORS:20190405-170314164
- 669198
- European Research Council (ERC)
- 098287/Z/12/Z
- Wellcome Trust
- Leverhulme Trust
- Created
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2019-04-09Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field