Published December 2009
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Design of insulating devices for in vitro synthetic circuits
Chicago
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Abstract
This paper describes a synthetic in vitro genetic circuit programmed to work as an insulating device. This circuit is composed of nucleic acids, which can be designed to interact according to user defined rules, and of few proteins that perform catalytic functions. A model of the circuit is derived from first principle biochemical laws. This model is shown to exhibit time-scale separation that makes its output insensitive to downstream time varying loads. Simulation results show the circuit effectiveness and represent the starting point for future experimental testing of the device.
Additional Information
© 2009 IEEE. Research supported in part by the Institute for Collaborative Biotechnologies through grant DAAD19-03-D-0004 from the U.S. Army Research Office. The authors would like to thank Erik Winfree, Friedrich Simmel and Jongmin Kim for helpful discussions and advise regarding the design and synthesis of in vitro genetic circuits.Attached Files
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Additional details
- Eprint ID
- 94048
- Resolver ID
- CaltechAUTHORS:20190322-103804228
- Army Research Office (ARO)
- DAAD19-03-D-0004
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2019-03-22Created from EPrint's datestamp field
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2021-11-16Created from EPrint's last_modified field