Lineage does not regulate the connectivity of projection neurons in the mouse olfactory bulb
- Creators
- Sánchez-Guardado, Luis
- Lois, Carlos
Abstract
Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to label neuronal progenitors sparsely and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.
Additional Information
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. We are grateful to Walter G. Gonzalez and Antuca Callejas for comments on the manuscript.Attached Files
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Additional details
- Eprint ID
- 94037
- Resolver ID
- CaltechAUTHORS:20190322-081916788
- Created
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2019-03-22Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field