Dynamics of Co-Translational Membrane Integration
- Creators
- Miller, Thomas F.
Abstract
Although proteins are synthesized only in specialized cellular locations, they are destined for delivery to all corners of the cell—and beyond. A key step in this delivery process is the efficient transport, or translocation, of the newly synthesized proteins across cell membranes, which involves a delicate balance between molecular processes. Recent studies offer high-resolution glimpses into the translocation process, but many fundamental aspects of its mechanism and regulation remain poorly understood. I will present our lab's efforts to computationally simulate the protein translocation process and to predict ways of controlling the in vivo targeting and delivery of proteins. This work employs methods that span across atomistic simulation, coarse-grained methods, machine learning techniques, and experimental collaborations.
Additional Information
© 2019 Biophysical Society. Available online 15 February 2019.Additional details
- Eprint ID
- 92970
- Resolver ID
- CaltechAUTHORS:20190219-103922051
- Created
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2019-02-19Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field