Electrospun nanofiber-based niflumic acid capsules with superior physicochemical properties
Abstract
The aim of this study was to assess whether nanofibrous drug mats have potential as delivery systems for poorly water-soluble drugs. Amorphous nanofiber mats from a model poorly water-soluble active pharmaceutical ingredient (API), niflumic acid, together with the polymer excipient, polyvinyl pyrrolidine, were prepared by nozzle-free electrospinning. This technique offers a scalable way for drug formulation, and by increasing the surface area of the drug, the dissolution rate and therefore bioavailability of the API can be improved. In this study, both the amount of the dissolved active ingredient and the dissolution kinetics has been improved significantly when the nanofibrous mats were used in the drug formulation. A 15-fold increase in the dissolved amount of the produced amorphous niflumic acid nanofiber was observed compared to the dissolved amount of the raw drug within the first 15 minutes. Capsule formulation was made by mixing the electrospun nanofibers with a microcrystalline cellulose filler agent. When comparing the dissolution rate of the capsule formulation on the market with the nanofibrous capsules, a 14-fold increase was observed in the dissolved drug amount within the first 15 minutes.
Additional Information
© 2019 Elsevier B.V. Received 9 December 2018, Revised 20 January 2019, Accepted 23 January 2019, Available online 23 January 2019.Additional details
- Eprint ID
- 92472
- Resolver ID
- CaltechAUTHORS:20190125-112844156
- 20391-3/2018/FEKUSTRAT
- Emberi Eroforrások Minisztériuma
- Created
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2019-01-25Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field