Published February 1, 2019
| Accepted Version
Journal Article
Open
Atroposelective Synthesis of PINAP via Dynamic Kinetic Asymmetric Transformation
Abstract
The atroposelective synthesis of PINAP ligands has been accomplished via a palladium‐catalyzed C−P coupling process through dynamic kinetic asymmetric transformation. These catalytic conditions allow access to a wide variety of alkoxy‐ and benzyloxy‐substituted PINAP ligands in high enantiomeric excess. The methods described in this communication afford valuable P,N ligands in good yields and high enantioselectivity using low catalyst loading.
Additional Information
© 2018 WILEY‐VCH Verlag. Issue Online: 01 February 2019; Version of Record online: 07 December 2018; Accepted manuscript online: 08 November 2018; Manuscript revised: 08 November 2018; Manuscript received: 18 September 2018. The authors wish to thank NIH‐NIGMS (R01GM080269), Amgen, the Gordon and Betty Moore Foundation, the Caltech Center for Catalysis and Chemical Synthesis, and Caltech for financial support. S.‐J.H. thanks the Fulbright program (Foreign Student Program, No. 15111120), the Ilju Foundation of Education & Culture (Pre‐doctoral Research Fellowship), and the KIST institutional program (2E28570, 2E28010) for financial support.Attached Files
Accepted Version - Han_et_al-2018-Advanced_Synthesis__26_Catalysis.pdf
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Han_et_al-2018-Advanced_Synthesis__26_Catalysis.pdf
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Additional details
- Eprint ID
- 90863
- Resolver ID
- CaltechAUTHORS:20181113-112609134
- R01GM080269
- NIH
- Amgen
- Gordon and Betty Moore Foundation
- Caltech Center for Catalysis and Chemical Synthesis
- 15111120
- Fulbright Foundation
- Ilju Foundation of Education & Culture
- 2E28570
- Korea Institute of Science and Technology (KIST)
- 2E28010
- Korea Institute of Science and Technology (KIST)
- Created
-
2018-11-14Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field