Published February 21, 2008
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Label-free detection of cytokines using optical microcavities
Chicago
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Abstract
Ultra-high-Q microresonators have demonstrated sensitive and specific chemical and biological detection. The sensitivity is derived from the long photon lifetime inside the cavity and specificity is achieved through surface functionalization. Here, ultra-high-Q microcavities demonstrate label-free, single molecule detection of Interleukin-2 (IL-2) in fetal bovine serum (FBS). IL-2 is a cytokine released in response to immune system activation. The surface of the microtoroids was sensitized using anti-IL-2. The detection mechanism relies upon a thermo-optic mechanism to enhance resonant wavelength shifts induced through binding of a molecule.
Additional Information
© 2008 Society of Photo-optical Instrumentation Engineers (SPIE). The authors would like to thank Prof. Richard Flagan and Dr. Rajan Kulkarni, for numerous helpful discussions. A.M. Armani is supported by a Clare Boothe Luce Post-doctoral Fellowship. This work was supported by the DARPA Center for OptoFluidic Integration.Attached Files
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Additional details
- Eprint ID
- 90800
- Resolver ID
- CaltechAUTHORS:20181109-125349088
- Clare Boothe Luce Postdoctoral Fellowship
- Defense Advanced Research Projects Agency (DARPA)
- Created
-
2018-11-14Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 6862